50 Cent is speaking for the first time about rumors he and talk show host Chelsea Handler are dating.

PHOTO: 50 Cent And Chelsea In Bed Together

As Breaking Celebrity News previously reported, Handler has made numerous on-air jokes at the rapper's expense to dispel romance rumors but curiously posted a photo of the pair — in bed — on Twitter in December.

Now the the rapper-turned-actor tells Access Hollywood the two are not involved.