by Breaking Celebrity News Staff

By George, they're through.

Yes, we've learned that George Clooney and Italian model Elisabetta Canalis have split up.

"We are not together anymore," the couple said in a statement Wednesday. "It's very difficult and very personal, and we hope everyone can respect our privacy."

Style Gallery: Evolution of George Clooney

The Up In The Air hunk, who turned 50 last month, had been seen with the shapely 32-year-old beauty bouncing between her native Italy and the U.S. over the past two years.