By Debbie Emery - Breaking Celebrity News Reporter

The sudden death of Mary Kennedy Wednesday has added to the long list of tragedies that has plagued the famous family for generations.

As Breaking Celebrity News was first to report, the estranged wife of Robert F. Kennedy Jr. was found at her Mount Kisco, New York home.

RFK Jr., 58, is the son of former Sen. Robert F. Kennedy and the nephew of President John F. Kennedy, and the couple had filed for divorce in May 2010 after 16 years of marriage and four children.

Mary’s death is yet another blow to the family who has endured such a string of heartbreaking events over the decades that it has sparked the phrase “The Kennedy Curse.”

The bad luck can be traced back to the 1940s with Rosemary Kennedy (JFK’s sister), who was born mentally challenged and began suffering from such increasingly violent mood swings that at age 23 she was given a lobotomy and remained institutionalized until her death.

Joseph "Joe" Kennedy Jr. was John’s older brother and expected to be the political face of the family, but before he could run for office the dashing pilot was shot down and killed in action during World War II while stationed in England.

After their fairytale wedding in September 1953, John F. Kennedy and Jacqueline Bouvier suffered double heartbreak when their daughter, Arabella, was stillborn in 1956, followed by their son, Patrick, dying at just two days old in August 1963 from infant respiratory distress syndrome.

The most infamous example of the curse is the assassination of President John F. Kennedy who was shot and killed while traveling in a motorcade through Dallas, Texas, on November 22, 1963. An investigation by the Warren Commission concluded that he was killed by lone gunman Lee Harvey Oswald, but there have been countless conspiracy theories over the decades that have suggested a plot or a cover-up.