Relentless Rose McGowan has decided to make Oprah Winfrey her next enemy.

The 47-year-old actress and sexual assault survivor took to Twitter on Sunday to trash the 67-year-old media personality, who is also a sexual assault survivor.

In the unprecedented rant, McGowan accused Winfrey of being fake, being friends with exiled movie producer Harvey Weinstein and somehow "destroying" disgraced music producer Russell Simmons' alleged victims.

The vile message was accompanied by an undated photo of a younger-looking Oprah kissing a younger-looking Harvey on the cheek at what appeared to be some sort of event or awards show.

"I am glad more are seeing the ugly truth of @Oprah," Rose posted and pinned to her page on Aug. 29, tagging the best-selling author and former talk show host. "I wish she were real, but she isn't."

"From being pals with Weinstein to abandoning & destroying Russell Simmon's [sic] victims, she is about supporting a sick power structure for personal gain," she continued. "She is as fake as they come."

McGowan went on to add, "#lizard," which – according to the internet – is "a metaphor for bad leadership and a culture of followership that doesn't feel capable of calling out."

Weinstein – whose lengthy list of alleged sexual assaults dates back to the 1970s – was the catalyst for the far-reaching #MeToo movement, which began in October of 2017 and has since helped hold abusers of power across all industries accountable for sexual harassment and misconduct.

McGowan was one of the first of dozens of alleged victims to publicly come forward with claims against Weinstein, who was found guilty of two felonies last February and will likely spend the rest of his life behind bars.

Aside from the seemingly years-old image of Harvey and Oprah, it is unclear what kind of relationship – if any – they had or have.